https://www.stbaldricks.org/fundraisers/buytramadolonlineovernightdeliverywithpaypal
https://www.stbaldricks.org/fundraisers/wheretoordertramadolonlinecheapwithnorx
https://www.stbaldricks.org/fundraisers/purchasetramadolonlineinminuteslightningepaycheckout
https://www.stbaldricks.org/fundraisers/purchasetramadolonlineinminuteslightningepaycheckout
https://www.stbaldricks.org/fundraisers/howtogettramadolonlineovernightwithedoctorapproval
https://www.stbaldricks.org/fundraisers/buycheaptramadolonlinenextdaydelivery30offepayorders
https://www.stbaldricks.org/fundraisers/buytramadol100mgonlineforarthritisbackpain24hourdelivery
https://www.stbaldricks.org/fundraisers/ordertramadol50mgonlineforfibromyalgialightningecheckout
https://www.stbaldricks.org/fundraisers/wheretopurchasetramadol200mgonlineforsciatica
https://www.stbaldricks.org/fundraisers/buytramadolonlineforneuropathybursitis100mgtabletsinstock
https://www.stbaldricks.org/fundraisers/buytramadolonlineforpostsurgicalpain50mgor100mg
https://www.pelotonia.org/profile/OC1076802
https://www.pelotonia.org/profile/WF1076809
https://www.pelotonia.org/profile/PS1076812
https://www.pelotonia.org/profile/TN1076818
https://www.pelotonia.org/profile/BF1076826
https://www.pelotonia.org/profile/OA1076832
https://www.pelotonia.org/profile/TM1076837
https://www.pelotonia.org/profile/BP1076841
https://www.pelotonia.org/profile/OP1076845
https://www.pelotonia.org/profile/TM1076849
https://tiltify.com/@buy-tramadol-online-overnight-delivery-with-paypal
https://tiltify.com/+order-tramadol-online-get-pills-in-30-minutes-with-e-card-payment
https://tiltify.com/+purchase-tramadol-online-cheap-next-day-delivery-and-no-prescription
https://tiltify.com/+buy-tramadol-online-50-off-today-100mg-overnight-paypal
https://tiltify.com/+order-tramadol-online-cheap-bogo-deal-50mg-e-pay-no-rx
https://tiltify.com/+purchase-tramadol-online-30-off-bulk-orders-100mg-instant-delivery
https://tiltify.com/+where-to-buy-tramadol-online-with-paypal-50-off-first-order
https://tiltify.com/+instant-tramadol-online-buy-2-get-1-free-100mg-e-card-pay
https://tiltify.com/+purchase-tramadol-online-overnight-25-off-reorders-50mg-tele-health
https://tiltify.com/+buy-cheap-tramadol-online-flash-sale-60-off-100mg-e-payment
https://give.water.org/fundraiser/14303/
https://give.water.org/fundraiser/14307/
https://give.water.org/fundraiser/14312/
https://give.water.org/fundraiser/14332/
https://give.water.org/fundraiser/14338/
https://give.water.org/fundraiser/14343/
https://give.water.org/fundraiser/14348/
https://give.water.org/fundraiser/14350/
https://give.water.org/fundraiser/14354/
https://give.water.org/fundraiser/14355/
https://www.jetphotos.com/photographer/598800
https://www.jetphotos.com/photographer/598801
https://www.jetphotos.com/photographer/598803
https://www.jetphotos.com/photographer/598805
https://www.jetphotos.com/photographer/598807
https://www.jetphotos.com/photographer/598808
https://www.jetphotos.com/photographer/598809
https://www.jetphotos.com/photographer/598810
https://www.jetphotos.com/photographer/598811
https://www.jetphotos.com/photographer/598813
https://janitorai.com/profiles/2a83fc89-18de-48d3-bf1f-5ae016a9071a_profile-of-buy-tramadol-online-fast-acting-100-mg-tablets-with-e-pay-overnight-shipping
https://janitorai.com/profiles/99fefcf7-dec2-4bf5-80bf-a23ba6ff8ff7_profile-of-order-tramadol-online-without-prescription-50-mg-capsules-for-neuropathic-pain
https://janitorai.com/profiles/f1e158f6-98d1-41b1-a943-d5211d056ce2_profile-of-purchase-tramadol-online-cheap-200-mg-er-tablets-for-chronic-pain-lightning-delivery
https://janitorai.com/profiles/29c37fda-56ac-4d23-a1f4-13c3b2b6e4bd_profile-of-buy-tramadol-online-in-ohio-instant-e-script-approval-50-mg-100-mg-options
https://janitorai.com/profiles/60df8145-f883-4789-8771-63c9ce0282d3_profile-of-order-tramadol-online-with-pay-pal-100-mg-pills-for-post-op-recovery-next-day
https://janitorai.com/profiles/271a91a5-2503-44af-80cd-136fce19aeaf_profile-of-purchase-tramadol-online-overnight-50-mg-quick-dissolve-tablets
https://janitorai.com/profiles/53d074c3-3a4c-4759-909c-64b08ad3a9b6_profile-of-buy-tramadol-online-trusted-e-vendor-with-lightning-delivery-pay-pal
https://janitorai.com/profiles/a9bf4811-5afb-43eb-a5a2-34da4863852b_profile-of-order-tramadol-without-prescription-discreet-overnight-shipping-nationwide
https://janitorai.com/profiles/fdaddb57-4e38-4ed4-8436-244e8dcd7dec_profile-of-purchase-tramadol-cheap-budget-friendly-pills-with-e-card-payment-options
https://janitorai.com/profiles/af6ad172-ac61-4193-ab59-7377b8d80730_profile-of-where-to-buy-tramadol-online-safely-legit-sources-compared
https://www.stbaldricks.org/fundraisers/buyxanaxonlineovernightfastdeliveryin30minutesxanax1mg2mg
https://www.stbaldricks.org/fundraisers/wheretoorderxanaxonlinewithoutprescriptionepaycarryout
https://www.stbaldricks.org/fundraisers/purchasexanaxpillsonlinenextdaydeliveryxanaxforanxietyinsomnia
https://www.stbaldricks.org/fundraisers/howtogetxanaxonlineinstantlynorxemeddigitalpayment
https://www.stbaldricks.org/fundraisers/xanaxonlinecheapovernightusdeliveryxanax2mgbars
https://www.stbaldricks.org/fundraisers/buyxanaxonlinewithpaypaltelehealthapprovednorxneeded
https://www.stbaldricks.org/fundraisers/xanaxonlineforpanicdisorders247fastshipping1mg2mgdoses
https://www.stbaldricks.org/fundraisers/canyoureallybuyxanaxonlinewithoutaprescriptionlegitevendor
https://www.stbaldricks.org/fundraisers/orderxanaxbarsonlinepfizer2mgnextdaydeliveryguaranteed
https://www.stbaldricks.org/fundraisers/xanaxforinsomniasleepbettertonightovernightdelivery
https://www.pelotonia.org/profile/BF1077245
https://www.pelotonia.org/profile/OI1077251
https://www.pelotonia.org/profile/HO1077252
https://www.pelotonia.org/profile/GO1077257
https://www.pelotonia.org/profile/XN1077264
https://www.pelotonia.org/profile/BL1077268
https://www.pelotonia.org/profile/OP1077271
https://www.pelotonia.org/profile/PW1077276
https://www.pelotonia.org/profile/WI1077278
https://www.pelotonia.org/profile/BW1077283
https://tiltify.com/@buy-xanax-online-for-anxiety-fast-overnight-delivery
https://tiltify.com/+order-xanax-online-for-panic-disorder-instant-e-payment-and-cheap-pills
https://tiltify.com/+purchase-xanax-online-for-insomnia-next-day-shipping-and-no-rx-needed
https://tiltify.com/+how-does-xanax-help-with-social-anxiety-buy-online-with-e-doctor-approval
https://tiltify.com/+xanax-online-for-generalized-anxiety-overnight-delivery-and-paypal-accepted
https://tiltify.com/+buy-cheap-xanax-online-for-ptsd-lightning-fast-shipping-and-e-pay
https://tiltify.com/+order-xanax-online-for-muscle-spasms-no-prescription-and-instant-delivery
https://tiltify.com/+can-xanax-treat-agoraphobia-purchase-online-with-next-day-shipping
https://tiltify.com/+order-xanax-online-for-ocd-symptoms-cheap-tablets-and-e-card-payments
https://tiltify.com/+buy-xanax-online-for-depression-related-anxiety-overnight-and-no-rx
https://give.water.org/fundraiser/14673/
https://give.water.org/fundraiser/14674/
https://give.water.org/fundraiser/14678/
https://give.water.org/fundraiser/14683/
https://give.water.org/fundraiser/14686/
https://give.water.org/fundraiser/14695/
https://give.water.org/fundraiser/14698/
https://give.water.org/fundraiser/14702/
https://www.jetphotos.com/photographer/598994
https://www.jetphotos.com/photographer/599000
https://www.jetphotos.com/photographer/599004
https://www.jetphotos.com/photographer/599006
https://www.jetphotos.com/photographer/599011
https://www.jetphotos.com/photographer/599018
https://www.jetphotos.com/photographer/599025
https://www.jetphotos.com/photographer/599028
https://www.jetphotos.com/photographer/599033
https://www.jetphotos.com/photographer/599041
https://janitorai.com/profiles/0ab3c597-83a6-46ad-8d46-3b3800ca19ff_profile-of-buy-xanax-online-for-severe-anxiety-attacks
https://janitorai.com/profiles/3f56539d-6418-4f77-9589-c2c3b50c79c2_profile-of-buy-xanax-online-overnight-fast-delivery-pay-pal-accepted
https://janitorai.com/profiles/be9e49e5-d6f0-45f3-b0bd-46f5e0d6cde1_profile-of-order-xanax-online-cheap-lightning-fast-30-minute-processing
https://janitorai.com/profiles/596463db-c41c-4339-aafe-973f5c547657_profile-of-purchase-xanax-online-without-prescription-instant-e-doctor-approval
https://janitorai.com/profiles/4cc45920-ff67-4ff4-bc99-0e1e3b59ca1b_profile-of-where-to-buy-xanax-online-with-next-day-delivery
https://janitorai.com/profiles/76b11510-1027-49ee-8b2e-d3bee0e1b3ec_profile-of-buy-xanax-online-overnight-e-payment-no-rx-required
https://janitorai.com/profiles/6cfcb701-80cc-4441-8080-913f6d229a57_profile-of-buy-xanax-online-with-e-payment-anonymous-fast-2-hour-delivery
https://janitorai.com/profiles/a7522187-dd67-439a-a139-76da1b09ef50_profile-of-order-xanax-2-mg-online-strongest-dose-for-severe-anxiety-disorders
https://janitorai.com/profiles/c3636fc3-13ca-47cf-982d-6c377cf607b9_profile-of-how-to-get-xanax-online-without-prescription-legally-tele-health-solution
https://janitorai.com/profiles/dc6dc848-4704-41ec-81ee-e18564988762_profile-of-xanax-for-insomnia-buy-sleep-aid-pills-online-with-overnight-shipping
https://raiseyourway.donordrive.com/campaigns/Buy-Cheap-Xanax-Online-Discount-Pills-for-GeneralizedAnxiety
https://raiseyourway.donordrive.com/campaigns/Buy-Xanax-Online-with-Overnight-Shipping---Anxiety-Relief-in
https://raiseyourway.donordrive.com/campaigns/Order-Xanax-1mg-Online---Trusted-E-Pharmacy-with-Lightning
https://raiseyourway.donordrive.com/campaigns/-Purchase-Xanax-Online-Without-Prescription---Discreet-E-Doc
https://raiseyourway.donordrive.com/campaigns/Where-to-Buy-Xanax-2mg-Online-with-Guaranteed-Delivery
Identification
Summary
Tramadol is a centrally-performing opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) employed for the management of average to severe soreness in adults.
manufacturer Names
Conzip, Durela, Qdolo, Ralivia, Ryzolt, Tridural, Ultracet, Ultram, Zytram
Generic identify
Tramadol
DrugBank Accession quantity
DB00193
history
Tramadol is really a centrally performing artificial opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is certainly structurally relevant to codeine and morphine. as a result of its good tolerability profile and multimodal mechanism of motion, tramadol is normally considered a decreased-threat opioid selection for the therapy of moderate to intense ache. It is considered a phase two possibility on the planet wellness Firm's soreness ladder and has about one/tenth of your potency of morphine.
Tramadol differs from other standard opioid medicines in that it does not just work as a μ-opioid agonist, but also has an effect on monoamines by modulating the results of neurotransmitters linked to the modulation of ache for instance serotonin and norepinpehrine which activate descending discomfort inhibitory pathways.13 Tramadol's results on serotonin and norepinephrine mimic the results of other SNRI antidepressants for instance duloxetine and venlafaxine.
Tramadol exists like a racemic mixture consisting of two pharmacologically Energetic enantiomers that the two add to its analgesic house by way of different mechanisms and are themselves metabolized into Lively metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists in the μ opioid receptor whilst (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits norepinephrine reuptake. These pathways are complementary and synergistic, increasing tramadol's capacity to modulate the notion of and reaction to suffering.twelve,twenty five
Tramadol has also been revealed to impact a number of other discomfort modulators in the central nervous system and non-neuronal inflammatory markers and immune mediators.seventeen,eighteen,20,26,sixteen Due to the wide spectrum of targets involved with suffering and inflammation, it is not shocking the evidence has revealed that tramadol is productive for numerous suffering types like neuropathic discomfort, put up-operative ache, reduce back suffering, in addition to pain connected with labour, osteoarthritis, fibromyalgia, and most cancers. because of its SNRI activity, tramadol also has anxiolytic, antidepressant, and anti-shivering effects which might be all usually found as comorbidities with soreness.sixteen
just like other opioid medicines, tramadol poses a hazard for advancement of tolerance, dependence and abuse. If used in larger doses, or with other opioids, there is a dose-relevant threat of check here overdose, respiratory melancholy, and death.22,37 However, unlike other opioid remedies, tramadol use also carries a chance of seizure and serotonin syndrome, especially if applied with other serotonergic drugs.23,24
Modality
smaller Molecule
teams
Approved, Investigational
Structure
bodyweight
normal: 263.381
Monoisotopic: 263.188529049
Chemical method
C16H25NO2
Synonyms
Tramadol
Tramadolum
External IDs
CG 315E
CG-315E
E-265
E265
ETS-6103
ETS6103
U-26255A
The New normal in Drug study
The next evolution of DrugBank is right here. made for experts, driven by AI, and run by actual-time insights. This can be drug intelligence, redefined.
https://www.stbaldricks.org/fundraisers/mypage/14696/2025
https://www.stbaldricks.org/fundraisers/mypage/14799/2025
https://www.stbaldricks.org/fundraisers/mypage/14868/2025
https://www.stbaldricks.org/fundraisers/mypage/14890/2025
https://www.stbaldricks.org/fundraisers/mypage/14908/2025
https://www.stbaldricks.org/fundraisers/mypage/14935/2025
https://www.stbaldricks.org/fundraisers/mypage/14950/2025
https://www.stbaldricks.org/fundraisers/mypage/14957/2025
https://www.stbaldricks.org/fundraisers/mypage/14960/2025
https://www.stbaldricks.org/fundraisers/mypage/14970/2025
https://medium.com/@kinan.shlomo/when-stress-steals-sleep-know-what-happens-inside-the-brain-12a7ac2c701a